
姓名:付小哲
職稱:研究員
學歷、學位:研究生、博士
聯(lián)系電話:18022410260
電子郵件:fuxiaozhe-1998@163.com
個人簡介:
女,1978年出生,研究員、博士、碩士生導師。圍繞嚴重危害我國鱖鱸鱧等名優(yōu)魚類主要病毒病,從細胞庫&病原庫建立、病毒致病機制、疫苗構建及質量控制技術等方面,開展魚類病毒病防治關鍵技術研究。其中研制的鱖傳染性脾腎壞死病毒及彈狀病毒二聯(lián)滅活疫苗成功獲得成果轉讓。先后主持、參加國家重點研發(fā)計劃、國家科技支撐計劃、國家自然科學基金、國家863、948項目、省級專項等各類科研項目等各級項目20多項。獲省、市級科技獎勵4項;授權國家發(fā)明專利19項;發(fā)表學術論文150余篇(第一作者或通訊作者40余篇),其中SCI論文60余篇(第一作者或通訊作者40余篇,其中IF>9.0有3篇);制定農業(yè)行業(yè)標準2項、廣東省標準1項;先后參編著作《湖北名優(yōu)魚健康養(yǎng)殖技術體系研究》、《獸醫(yī)生物制品學》(第2版)。被聘為安徽省農業(yè)農村柔性引進人才。
研究方向:
1.魚類病毒致病機制
2.魚類病毒病疫苗研制
3.疫苗免疫機制
社會兼職:
Fish and Shellfish Immunology、Aquaculture、Vaccine等多個刊物審稿人。
高校校外導師兼職情況:
1.上海海洋大學碩士生導師
2.大連海洋大學碩士生導師
3.天津農學院碩士生導師
獲獎情況:
1.中國水產科學研究院科學技術一等獎“鱖鱸鱧病毒病全鏈條精準防控關鍵技術研究與示范”(第3完成人,2023)
2.廣東省農業(yè)技術推廣獎二等獎“鱖魚免疫與生態(tài)防控技術示范與推廣” (第8完成人,2019)
3.中國水產科學研究院科技進步三等獎“廣譜、高效海水魚弧菌病重組OmpK亞單位疫苗創(chuàng)制與轉基因生物安全評價”(第6完成人,2015)
4.中國水產科學研究院科技進步一等獎“海水養(yǎng)殖魚類哈維氏弧菌、溶藻弧菌二聯(lián)疫苗研究”,第十三完成人(第13完成人,2009)
近幾年代表性論文及其他代表性成果:
1. Xiaozhe Fu, Wenxian Li, Cong Liu, Xia Luo, Qiang Lin, Yinjie Niu, Hongru Liang, Baofu Ma, Ningqiu L. A naturaly attenuated largemouth bass ranavirus strain provided protection for Micropterus salmoides by immersion immunization. Fish and Shellfish Immunology, 2024, 153, 109871
2. Xiaozhe Fu, Mingju Luo, Qiang Lin, Hongru Liang, Yinjie Niu, Xia Luo, Baofu Ma and Ningqiu Li. An Avirulent Largemouth Bass Birnavirus Vaccine Candidate
Protects Largemouth Bass against Birnavirus Infection. Vaccines 2023, 11, 1740
3. Xiaozhe Fu, Kejin Li, Yinjie Niu, Qiang Lin, Hongru Liang, Xia Luo, Lihui Liu, Ningqiu Li. The mTOR/PGC-1a/SIRT3 Pathway Drives Reductive Glutamine Metabolism to Reduce Oxidative Stress Caused by ISKNV in CPB Cells. Microbiology spectrum, 2022, 10 (1): e02310-21
4. Caimei Ye, Shangui Liu, Ningqiu Li, Shaozhi Zuo, Yinjie Niu, Qiang Lin, Hongru Liang, Xia Luo, Xiaozhe Fu*. Mandarin Fish (Siniperca chuatsi) p53 Regulates Glutaminolysis Induced by Virus via the p53/miR145-5p/c-Myc Pathway in Chinese Perch Brain Cells. Microbiology spectrum, 2022, 10 (2) : 10.1128/spectrum.02727-21
5. Xiaozhe Fu, Mingju Luo, Guo Zheng, Hongru Liang, Lihui Liu, Qiang Lin, Yinjie Niu, Xia Luo, Ningqiu Li. Determination and Characterization of a Novel Birnavirus Associated with Massive Mortality in Largemouth Bass. Microbiology spectrum, 2022, 10 (2) : 10.1128/spectrum.01716-21
6. Shangui Liu, Ningqiu Li, Qiang Lin, Lihui Liu, Yinjie Niu, Hongru Liang, Zhibin Huang, Xiaozhe Fu*. Glutaminase 1 in mandarin fish Siniperca chuatsi: Molecular characterization, expression pattern and function involving in virus replication. Aquaculture, 2020, 519, 734924
7. Xiaozhe Fu, Lixi Zhang, Lihui Liu, Qiang Lin, Hongru Liang, Yinjie Niu, Zhibin Huang, Ningqiu Li. Identification of intron in ORF003 gene and its application for inactivation test of ISKNV. Microbial Pathogenesis, 2020, 138, 103822
8. Yinjie Niu, Peng Zhang, Luyao Wang, Ningqiu Li, Qiang Lin, Lihui Liu, Hongru Liang, Zhibin Huang, Xiaozhe Fu?. Development of double-antibody sandwich ELISA for rapidly quantitative detection of antigen concentration in inactivated SCRV vaccine. Aquaculture, 2020, 520: 734671
9. Xiaozhe Fu, Yue Ming, Chen Li, Yinjie Niu, Qiang Lin, Lihui Liu, Hongru Liang, Zhibin Huang, Ningqiu Li. Siniperca chuatsi rhabdovirus (SCRV) induces autophagy via PI3K/Akt-mTOR pathway in CPB cells. Fish shellfish immunology, 2020, 102: 381-388
10. Zhao Zhao, Chen Zhang, Qiang Lin, Ning-qiu Li, Zhi-Bin Huang, Mi Zhao, Xiao-Zhe Fu?, Gao-Xue Wang, Bin Zhu. Single-walled carbon nanotubes as delivery vehicles enhance the immunoprotective effect of an immersion DNA vaccine against infectious spleen and kidney necrosis virus in mandarin fish. Fish and Shellfish Immunology, 2020, 432–439
11. 鱖傳染性脾腎壞死病毒(ISKNV)ORF093蛋白的應用, 國家發(fā)明專利, ZL 201110191339.0, 第一發(fā)明人.
12. 鱖魚腦細胞系的構建方法, 國家發(fā)明專利, ZL 201310202902.9, 第1發(fā)明人.
13. 一株魚類彈狀病毒弱毒疫苗株,國家發(fā)明專利,ZL201711325935.5,第1發(fā)明人。
14. 用于檢測鱖魚彈狀病毒的試劑盒,國家發(fā)明專利,ZL 201910139571.6,第1發(fā)明人。
15. ISKNV基因內含子及其在區(qū)分ISKNV活病毒與滅活病毒中的應用,ZL20161441036973.6, 第1發(fā)明人。